CJC-1295/Ipamorelin is a combination research preparation containing two complementary peptides: CJC-1295 (with Drug Affinity Complex) and Ipamorelin. CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 30 amino acids (modified GHRH(1-29)) with a molecular weight of approximately 3,367.97 Da. The Drug Affinity Complex (DAC) modification enables covalent binding to serum albumin, extending the compound’s half-life in preclinical models from minutes to days. Ipamorelin is a pentapeptide growth hormone secretagogue with the sequence Aib-His-D-2Nal-D-Phe-Lys-NH₂ and a molecular weight of approximately 711.85 Da.
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The mechanistic rationale for this combination lies in complementary receptor targeting. CJC-1295 acts through the GHRH receptor (GHRHR), a G-protein coupled receptor expressed on somatotroph cells, activating the cAMP/PKA signaling cascade. Ipamorelin selectively activates the growth hormone secretagogue receptor (GHS-R1a, ghrelin receptor) through a distinct signaling pathway. In pituitary cell culture models, concurrent activation of both receptor systems has demonstrated synergistic growth hormone release exceeding the sum of individual compound effects.
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Preclinical studies have characterized the selectivity profile of Ipamorelin, noting minimal effects on ACTH, cortisol, or prolactin release in pituitary explant models—distinguishing it from earlier GH secretagogues such as GHRP-6. CJC-1295 with DAC has demonstrated sustained GHRHR activation in albumin-containing media systems, modeling the extended pharmacokinetic profile observed in preclinical research.
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Research applications for this combination include GH axis physiology, somatotroph signaling crosstalk, receptor desensitization kinetics, and pulsatile hormone release modeling. The dual-receptor approach provides a valuable tool for distinguishing GHRH-dependent and ghrelin-dependent components of GH secretion in experimental systems.
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Erosyn Labs provides this combination as a lyophilized powder with each component at ≥98% purity by HPLC. Full Certificate of Analysis with identity and purity data for each peptide is included. Reconstitution in bacteriostatic water is recommended. Store lyophilized material at -20°C; reconstituted solutions at 2–8°C for up to 30 days.
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For research and laboratory use only. Not for human consumption.
